en بیوشیمی Biochemistry تحقيقي Original Paper <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> <i><span style="color:black">Telfairia occidentalis </span></i><span style="color:black">is </span>among<span style="color:black"> the most popular vegetable crops propagated in the West African rainforest zone for its green leafy vegetable and ellipsoidal fruit, which are highly nutritious</span>. This study investigated <span style="color:black">the liver&#39;s</span> synthetic ability and hematological profile potential of <i>T. occidentalis</i> against <span style="color:black">carbon </span>tetrachloride-induced toxicity in <span style="color:black">Wistar</span> rats.<br> <b>Methods:</b> Five experimental groups of rats were used in this study. One group received distilled water and served as the normal control. The second group received carbon tetrachloride (CCl₄) alone for four days. The third and fourth groups received CCl₄ for four days prior to treatment with 200 mg/kg and 400 mg/kg <i>T. occidentalis</i> aqueous extract for six days, respectively. The last group received CCl₄ for four days prior to treatment with silymarin (100 mg/kg) for six days. <span class="A1"><span style="color:black">With</span></span> the<span class="A1"><span style="color:black"> exception of normal control rats, all rats received a mixture of freshly prepared CCl</span></span><span class="A11"><span style="color:black">₄</span></span> <span class="A1"><span style="color:black">in olive oil (</span></span>1 ml<span class="A1"><span style="color:black">/kg, 1:1 intraperitoneally) for </span></span>four<span class="A1"><span style="color:black"> days</span></span>. The activities of liver synthetic molecules, such as total protein, albumin, and total bilirubin, as well as hematological parameters, were measured in the blood.<b><span style="font-size:8.0pt"></span></b><br> <b>Results:</b> CCl₄exposure and toxicity caused a significant (P < 0.05) increase in total bilirubin and white blood cells and a significant decrease in total protein, albumin, hemoglobin, hematocrit, red blood cells, and platelets. However, treatment with <i>T. occidentalis</i> aqueous extract significantly (P <span style="color:black">< 0.05</span>) ameliorated the levels of these markers toward normal values.<br> <b>Conclusion</b>: <i>T. occidentalis</i> aqueous extract exhibited enhancement of liver synthetic ability and hematological profile in CCl₄-induced toxicity.<span style="font-size:8.0pt"></span></span></span><br> &nbsp;</div> Antioxidants, Oxidative stress, Telfairia occidentalis 1 3 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1443-1&slc_lang=en&sid=1 Usunobun Usunomena usunobun.usunomena@edouniversity.edu.ng 100319475328460029155 100319475328460029155 Yes Department of Biochemistry, Faculty of Basic Medical Sciences, Edo State University Uzairue, Edo State, Nigeria Ambrose Emuobonuvie Akpovona aeakpovona@gmail.com 100319475328460029156 100319475328460029156 No Department of Biological and Chemical Sciences, Faculty of Natural and Applied Sciences, Michael and Cecilia Ibru University, Agbarha-Otor, Ughelli, Delta State, Nigeria