en فیزیولوژی ورزشی Sport Physiology تحقيقي Original Paper <span style="font-size:12px;"><span style="font-family:Times New Roman;"><b>Background:</b> Cardiovascular diseases, especially coronary artery problems, are the main causes of death. The aim of this study was to evaluate the expression of <i>NOs </i>and <i>NOX2</i> in coronary artery patients after aerobic exercise and omega-3 intake.<br> <b>Methods:</b> The present study was a quasi-experimental study in which 32 men with coronary artery disease in the age range of 55 to 65 years were selected and randomly divided into 4 groups: control, exercise, omega-3, and omega-3 + exercise. The training program consisted of 8 weeks of intermittent running training, 3 sessions per week, with an intensity of 55 to 65% of the subjects&#39; heart rate reserve and with an emphasis on gradual overload. Subjects consumed 1000 mg of omega-3 daily.<br> <b>Results:</b> There was a significant increase (P <0.0001) in the mean expression of the NOS gene in the exercise + omega-3 group compared to the control group. The mean ratio of <i>NOX</i> gene expression changes in the exercise group, omega-3, and the combination of exercise + omega-3 was significantly reduced compared to the control group (P <0.0001).<br> <b>Conclusion</b>: According to the results of the present study, the ability of exercise and omega-3 supplementation to reduce the level of oxidant stress and increase homeostasis control in coronary artery insufficiency shows an important molecular mechanism that underlies the benefits of these interventions.</span></span> Exercise, Omega3, Nos Protein, NOX2 Protein, Coronary Occlusion 12 15 http://mlj.goums.ac.ir/browse.php?a_code=A-10-980-1&slc_lang=en&sid=1 Sedigheh Shirkhani Shirkani_s79@yahoo.com 100319475328460027217 100319475328460027217 No Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran alireza barari alireza54.barari@gmail.com 100319475328460027218 100319475328460027218 Yes Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran Asieh Abbasi Daloii abbasi.daloii@gmail.com 100319475328460027219 100319475328460027219 No Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran mehrdad saravi mehrdadsaravi@gmail.com 100319475328460027220 100319475328460027220 No Department of Cardiology, Babol University of Medical Sciences, Babol, Iran